Case Report
A Case of Amoxycillin-Induced Pediatric Lyell Syndrome in a Provincial Hospital in the Democratic Republic of the Congo
Mireille Ngale*,
Thierry Mpengani,
Percy Velela,
Jean-Jacques Mbebo,
Tarcisse Kilara,
Silva Kasereka,
Gauthier Mesia,
Nsengi Ntamabyaliro,
Samuel Mampunza,
Gaston Tona
Issue:
Volume 3, Issue 1, April 2024
Pages:
1-4
Received:
5 December 2023
Accepted:
26 December 2023
Published:
18 January 2024
Abstract: Lyell syndrome is a rare and potentially fatal condition. It represents a serious cutaneous adverse drug reaction, often caused by drugs. Lyell syndrome and Steven-Johnson syndrome have an identical clinical expression and differ from each other only in the body surface area involved. They are characterized by the sudden destruction and detachment of the epidermis and mucous membranes. This is a drug allergy for which the mechanisms of onset are complex and involve many poorly understood pathophysiological factors. A 3-year-old girl presented with vulvar pruritus and a rash two days after self-medication with antibiotics and paracetamol to combat a fever. Phlyctenes and bullae then developed all over the body. The chronology of the occurrence of the signs, the spread of the lesions led to the diagnosis of Lyell syndrome. Lyell's syndrome is a rare condition and despite its low incidence, it is increasingly reported on the African continent. Although high, its mortality depends on several factors including the age of the patient, gender, and extent of lesions. Multidisciplinary collaboration and follow-up of the sequelae are crucial for the survival of the patient. Lyell syndrome is potentially fatal, but treatable with concerted management even in rural areas. The community and health workers should be warned of the potential danger of self-medication and irrational use of drugs.
Abstract: Lyell syndrome is a rare and potentially fatal condition. It represents a serious cutaneous adverse drug reaction, often caused by drugs. Lyell syndrome and Steven-Johnson syndrome have an identical clinical expression and differ from each other only in the body surface area involved. They are characterized by the sudden destruction and detachment ...
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Research Article
Climate Change Impacts on Malaria Incidence: A 10-Year Retrospective Analysis in Luapula and Southern Zambia
Joshua Kanjanga Phiri*,
Rosemary Ndonyo Likwa
Issue:
Volume 3, Issue 1, March 2024
Pages:
5-12
Received:
31 January 2024
Accepted:
12 February 2024
Published:
29 February 2024
Abstract: This study examines the impact of climate change on the incidence of malaria in Zambia. The study focused on variations in prevalence influenced by climatic and environmental factors. This study adopted a retrospective comparative analytical approach, utilizing 157 case records from each province. The survey investigated temperature, seasonal variations, and land use activities. Descriptive and inferential statistics were used to explore the relationships between malaria incidence and climate change. The findings revealed a high fluctuating trend of rainfall from 2010 to 2020, with an average annual rainfall of 1058.0 mm. The highest total rainfall was observed in 2017 (1434.4 mm), indicating a strong association between malaria incidence rates and rainfall, as supported by a significant p-value of 0.041. Additionally, an assessment of the annual percentage of drought area for each province showed that in 2019, Southern Province had the highest percentage of drought at 64% over the ten-year period. This resulted in a poor vegetation health index, creating unfavorable environmental conditions for mosquito larvae and leading to reduced malaria transmission in the southern region. Importantly, demographic data revealed distinct population distributions between provinces, with a significant urban-rural divide. The majority of the population in both provinces resided in rural areas, with 797,407 in Luapula Province and 1,197,751 in Southern Province. Despite southern province having a higher population distribution in rural areas, Luapula Province exhibited a higher number of malaria transmission cases over the ten-year period. These results emphasize the crucial role of climate change and local environmental factors in the dynamics of malaria transmission, highlighting the need for malaria control strategies tailored to specific regions in Zambia.
Abstract: This study examines the impact of climate change on the incidence of malaria in Zambia. The study focused on variations in prevalence influenced by climatic and environmental factors. This study adopted a retrospective comparative analytical approach, utilizing 157 case records from each province. The survey investigated temperature, seasonal varia...
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